In 2021 650,000 people died from AIDS-related mortality. This satellite will highlight key recommendations for reducing deaths due to advanced HIV disease, and summarize key gaps for future action. Leading experts will summarize challenges in addressing major pathogens, including toberculosis, cruytococcal meningitis, histoplasmosis, talaromyces, and other fungal infections. Speakers will include leaders from the three organizing agencies – WHO, UNITAID and CDC – as well as clinical researchers and programme managers from affected countries.