Despite tremendous progress in the global fight against HIV/AIDS evidenced by declining HIV incidence and expanded access to antiretroviral therapy, decline in AIDS-related deaths have plateaued. Up to half of PLHIV present to care with Advanced HIV disease (AHD). Individuals with AHD are at a higher risk of death even after starting ART, and are prone to opportunistic infections including TB, severe bacterial infections, malnutrition and cryptococcal meningitis. In 2021, there were an estimated 650,000 HIV-related deaths globally, including 95,000 children. The Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) supports governments in implementing AHD programs in 11 countries in Sub-Saharan Africa (SSA). SSA alone bears an estimated 60% of these deaths. With funding from PEPFAR, CDC, USAID and the Gates Foundation, EGPAF intends to highlight the programmatic lessons learned, and the real-world evidence generated from AHD program implementation in Malawi, Cote d’Ivoire and Lesotho.