Share
Title
Post-acute sequelae of COVID-19 (PASC) and Quality of Life in people with HIV
Presenter
Ever Arturo Corral Herrera
Authors
E.A. Corral Herrera1, B. Crabtree Ramírez1, A. López Íñiguez1, Y. Caro Vega1, M.F. Vargas Morales1, K. Juárez Campos1, A. Ortiz Hernández1, J.G. Sierra Madero1
Institutions
1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Infectious Diseases/HIV Clinic, Mexico City, Mexico

BACKGROUND: People with HIV (PWH) have a higher risk for severe disease due to SARS-CoV-2 infection. There are few studies on the frequency of PASC in PWH, the associated factors, and its impact on quality of life. We aim to analyze the frequency of PASC in PWH and its impact on quality of life among PWH in care at the HIV Clinic of a tertiary teaching Hospital (INCMNSZ).
METHODS: All individuals seen at the HIV Clinic from November to December of 2022, with a history of acute COVID-19 from January 1, 2021, to August 31, 2022, were included. Data were collected from the electronic chart. A validated questionnaire was conducted to collect data related to the episode of acute COVID-19 and PASC defined as the presence of persistent/new symptomatology or laboratory/radiological abnormalities 12 weeks after acute COVID-19 with no other cause in addition to an assessment of health-related quality of life using EuroQol-5D-5L (EQ-5D-5L) with values set for Mexican adult general population.
RESULTS: 399 individuals were seen at the HIV clinic during the study period, 103 had acute COVID-19 and 80 agreed to participate. All 80 participants were on ART during the study period, and 29(36%) had PASC according to the definition. Fatigue was the most frequent symptom (72%), followed by anxiety (52%), insomnia (52%) and headache (48%). The percentage of individuals with CD4 cell counts <200cel/mm3 was similar between participants with PASC vs without PASC (17% vs 10%,p=0.48), and also the percentage of participants with three doses of SARS-CoV-2 vaccination (90% vs 92%,p=0.69, respectively).
Female (p=0.023), overweight/obesity (p=0.03) and the presence of >3 comorbidities (p=0.0049) were more likely to be present in the PASC group. Individuals with PASC had a negative impact on quality of life (p=0.0007) and lower overall health status (p=0.01). Absence of PASC was associated significantly with greater perception of maximum health status (p=0.0003).
CONCLUSIONS: In a highly vaccinated population of PWH, PASC was a common finding (36%). Associated factors were being female, having overweight/obesity, and the presence of 3 or more comorbidities. Lower quality of life was observed in those with PASC. Comparative studies with non-HIV population are needed.

Download the e-Poster (PDF)

Download the e-Poster (Movie)